Tenth Annual Alliance for Healthy Aging Conference:
A Partnership of the Mayo Clinic Kogod Center on Aging,
The University Medical Center Groningen, and
Newcastle University Institute for Ageing
October 24-26, 2019

"Intervention: from Mice to Humans"

Slaley Hall Hotel, Hexham, Northumberland, UK


Thursday, 24 October 2019

15:00 – 17:00


Poster set up & Registration 

Location: Kielder Suite, Slaley Hall Hotel

17:00 – 17:05

Opening  and Welcome to the Tenth Annual Alliance for Healthy Aging Conference by Conference Co-Directors

Marco Demaria, PhD, University Medical Center Groningen

Diana Jurk, PhD, Mayo Clinic

Tamara Tchkonia, PhD, Mayo Clinic

Thomas von Zglinicki, PhD, Newcastle University

17:05 – 18:05

Keynote Speaker

Professor Dr Clemens Schmitt, MD

“Cross-species dissection and targeting of aging-reminiscent cancer cell senescence"

18:05 – 19:30

Reception and poster viewing, Kielder Suite

19:30 – 21:00

Dinner in Kielder Suite 


Friday, October 25

07:00 – 09:00

Breakfast in Hadrian’s Brasserie

08:00 – 09:00

Registration - entrance to Kielder Suite

Topic I – “Biological ageing and frailty”

Chairs: Sophia de Rooij, MD, PhD and Lene Rasmussen, PhD

09:00 – 09:25

Peter Adams, PhD

“Histone chaperone HIRA links developmental integrity to healthy aging”

09:25 – 09:50

David Gunn, BSc (Hons), DPhil

"Does it matter how old I look?"

09:50 – 10:15

Jeremy Walston, MD

"Physical Frailty in Older Adults:  Causes and Interventions"

10:15 – 10:40

Ken Rockwood, MD, MPA, FRCPC

"Deficit accumulation as a target in biological ageing"

10:40 – 10:50

Matt Yousefzadeh, PhD

“The aging immune system drives senescence and dysfunction of peripheral tissues”

10:50 – 11:10

Tea/coffee break

Topic II – “Reversing premature ageing”

Chairs: Claudio Franceschi, PhD and Sharukh Hashmi, MD, MPH 

11:10 – 11:35

Thomas von Zglinicki, PhD

“Reversing premature ageing in mice by senolytics and the senomorphic metformin”

11:35 – 12:00

Kirsten Ness, PT PhD FAPTA

“Remediating frail health in childhood cancer survivors”

12:00 – 12:25

Rob Coppes, PhD

“Elimination of radiation-induced senescent cells improves regenerative potential salivary gland stem cells”

12:25 – 12:50

Masashi Narita, MD, PhD

“Autophagy in ageing and age-associated spontaneous cancer”

12:50 – 13:00

Thijmen van Vliet

“Hypoxia restrains the pro-inflammatory senescence associated secretory phenotype (SASP)”

13:00 – 14:15

Lunch and poster viewing

Topic III – “Brain ageing/dementia”

Chairs: Johannes Attems, PhD and Joao Malva, PhD

14:15 – 14:40

Diana Jurk, PhD

“Cellular senescence: key driver of brain aging and anxiety”

14:40 – 15:05

Rodrigo Cunha, PhD

"Coffee & Ageing: memory impairment and synaptic dysfunction in aged rats critically depend on the over-functioning of the adenosine Azareceptor modulation system"

15:05 – 15:30

Miranda Orr, PhD

“Targeting tau-associated cellular senescence to mitigate neurodegeneration and cognitive impairment in age-associated brain diseases”

15:30 – 15:55

Julie Andersen, PhD

"Cellular senescence as a driver of neurodegenerative diseases"

15:55 – 16:05

Claudia Cavadas, PhD

“Neuropetide Y (NPY) Rescues Hallmarks Of Cellular Aging In Progeria Cells”

16:05 – 16:20

Tea/coffee break

Topic IV – “Vascular and metabolic ageing”

Chairs: Georgina Ellison Hughes, PhD and Folkert Kuipers, PhD

16:20 – 16:45

Jordan Miller, PhD

“Therapeutic strategies to alleviate cardiovascular multi-morbidity”

16:45 – 17:10

James Kirkland, MD, PhD

“Aging, Chronic Disease, and Senolytics: The Path to Translation”

17:10 – 17:35

Bart van de Sluis, PhD

“Targeting the endocytic system to combat atherosclerosis”

17:35 – 17:45

Ingo Lammermann, PhD

“Novel senolytics based on arachidonic acid metabolism”

17:45 – 19:45

Free Time

19:45 – 00:00

Drinks Reception, Gala Dinner and Dance - Kielder Suite

Saturday, 26 October 2019

07:00 - 09:00

Breakfast in Hadrian’s Brasserie

Topic V - “Muscular ageing and sarcopenia”

Chairs: Ilaria Bellantouno, MD, PhD and Anne McArdle, PhD

09:00 – 09:25

Avan Sayer, MBBS, PhD, FRCP

"Interventions for sarcopenia: a translational pipeline?"

09:25 – 09:50

Shalender Bhasin, MB, BS

“Translating Promyogenic Candidate Molecules into Approvable Drugs: Lessons from RCTs of AR Ligands and ActRIIB Ligand Traps”

09:50 – 10:15

Anne-Ulrike Trendelenburg, PhD

"Towards sarcopenia treatments: preclinical research and challenges"

10:15 – 10:40

Cédric Dray, PhD

"The new exerkine apelin reverses age-related sarcopenia"

10:40 – 10:50

Inna Ovsyannikova, PhD

“Immunosenescence and Influenza Vaccination in Older Individuals”

10:50 – 11:10

Tea/coffee break

Topic VI – “Extending healthspan”

Chairs: Erik Boddeke, PhD and Tom Kirkwood CBE, FMedSci, FRCP Edin 

11:10 – 11:35

Satomi Miwa, PhD

“Identifying drugs to extend healthspan: a novel approach, old concepts”

11:35 – 12:00

Paul Robbins, PhD

“Novel senotherapeutic approaches to extend healthspan”

12:00 – 12:25

Eduardo Chini, MD, PhD

"NAD metabolism in aging and disease"

12:25 – 12:50

John Speakman, PhD

“Impacts of graded calorie restriction”

12:50 – 13:00



Lunch in Hadrians Brasserie