Tenth Annual Alliance for Healthy Aging Conference:
A Partnership of the Mayo Clinic Kogod Center on Aging,
The University Medical Center Groningen, and
Newcastle University Institute for Ageing
October 24-26, 2019
"Intervention: from Mice to Humans"
Slaley Hall Hotel, Hexham, Northumberland, UK
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15:00 – 17:00
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Poster set up & Registration Location: Kielder Suite, Slaley Hall Hotel |
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17:00 – 17:05 |
Opening and Welcome to the Tenth Annual Alliance for Healthy Aging Conference by Conference Co-Directors Marco Demaria, PhD, University Medical Center Groningen Diana Jurk, PhD, Mayo Clinic Tamara Tchkonia, PhD, Mayo Clinic Thomas von Zglinicki, PhD, Newcastle University |
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17:05 – 18:05 |
Keynote Speaker Professor Dr Clemens Schmitt, MD “Cross-species dissection and targeting of aging-reminiscent cancer cell senescence" |
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18:05 – 19:30 |
Reception and poster viewing, Kielder Suite |
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19:30 – 21:00 |
Dinner in Kielder Suite |
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07:00 – 09:00 |
Breakfast in Hadrian’s Brasserie |
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08:00 – 09:00 |
Registration - entrance to Kielder Suite |
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Topic I – “Biological ageing and frailty” |
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Chairs: Sophia de Rooij, MD, PhD and Lene Rasmussen, PhD |
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09:00 – 09:25 |
Peter Adams, PhD “Histone chaperone HIRA links developmental integrity to healthy aging” |
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09:25 – 09:50 |
David Gunn, BSc (Hons), DPhil "Does it matter how old I look?" |
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09:50 – 10:15 |
Jeremy Walston, MD "Physical Frailty in Older Adults: Causes and Interventions" |
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10:15 – 10:40 |
Ken Rockwood, MD, MPA, FRCPC "Deficit accumulation as a target in biological ageing" |
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10:40 – 10:50 |
Matt Yousefzadeh, PhD “The aging immune system drives senescence and dysfunction of peripheral tissues” |
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10:50 – 11:10 |
Tea/coffee break |
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Topic II – “Reversing premature ageing” |
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Chairs: Claudio Franceschi, PhD and Sharukh Hashmi, MD, MPH |
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11:10 – 11:35 |
Thomas von Zglinicki, PhD “Reversing premature ageing in mice by senolytics and the senomorphic metformin” |
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11:35 – 12:00 |
Kirsten Ness, PT PhD FAPTA “Remediating frail health in childhood cancer survivors” |
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12:00 – 12:25 |
Rob Coppes, PhD “Elimination of radiation-induced senescent cells improves regenerative potential salivary gland stem cells” |
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12:25 – 12:50 |
Masashi Narita, MD, PhD “Autophagy in ageing and age-associated spontaneous cancer” |
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12:50 – 13:00 |
Thijmen van Vliet “Hypoxia restrains the pro-inflammatory senescence associated secretory phenotype (SASP)” |
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13:00 – 14:15 |
Lunch and poster viewing |
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Topic III – “Brain ageing/dementia” |
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Chairs: Johannes Attems, PhD and Joao Malva, PhD |
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14:15 – 14:40 |
Diana Jurk, PhD “Cellular senescence: key driver of brain aging and anxiety” |
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14:40 – 15:05 |
Rodrigo Cunha, PhD "Coffee & Ageing: memory impairment and synaptic dysfunction in aged rats critically depend on the over-functioning of the adenosine Azareceptor modulation system" |
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15:05 – 15:30 |
Miranda Orr, PhD “Targeting tau-associated cellular senescence to mitigate neurodegeneration and cognitive impairment in age-associated brain diseases” |
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15:30 – 15:55 |
Julie Andersen, PhD "Cellular senescence as a driver of neurodegenerative diseases" |
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15:55 – 16:05 |
Claudia Cavadas, PhD “Neuropetide Y (NPY) Rescues Hallmarks Of Cellular Aging In Progeria Cells” |
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16:05 – 16:20 |
Tea/coffee break |
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Topic IV – “Vascular and metabolic ageing” Chairs: Georgina Ellison Hughes, PhD and Folkert Kuipers, PhD |
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16:20 – 16:45 |
Jordan Miller, PhD “Therapeutic strategies to alleviate cardiovascular multi-morbidity” |
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16:45 – 17:10 |
James Kirkland, MD, PhD “Aging, Chronic Disease, and Senolytics: The Path to Translation” |
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17:10 – 17:35 |
Bart van de Sluis, PhD “Targeting the endocytic system to combat atherosclerosis” |
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17:35 – 17:45 |
Ingo Lammermann, PhD “Novel senolytics based on arachidonic acid metabolism” |
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17:45 – 19:45 |
Free Time |
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19:45 – 00:00 |
Drinks Reception, Gala Dinner and Dance - Kielder Suite |
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07:00 - 09:00 |
Breakfast in Hadrian’s Brasserie |
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Topic V - “Muscular ageing and sarcopenia” |
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Chairs: Ilaria Bellantouno, MD, PhD and Anne McArdle, PhD |
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09:00 – 09:25 |
Avan Sayer, MBBS, PhD, FRCP "Interventions for sarcopenia: a translational pipeline?" |
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09:25 – 09:50 |
Shalender Bhasin, MB, BS “Translating Promyogenic Candidate Molecules into Approvable Drugs: Lessons from RCTs of AR Ligands and ActRIIB Ligand Traps” |
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09:50 – 10:15 |
Anne-Ulrike Trendelenburg, PhD "Towards sarcopenia treatments: preclinical research and challenges" |
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10:15 – 10:40 |
Cédric Dray, PhD "The new exerkine apelin reverses age-related sarcopenia" |
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10:40 – 10:50 |
Inna Ovsyannikova, PhD “Immunosenescence and Influenza Vaccination in Older Individuals” |
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10:50 – 11:10 |
Tea/coffee break |
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Topic VI – “Extending healthspan” Chairs: Erik Boddeke, PhD and Tom Kirkwood CBE, FMedSci, FRCP Edin |
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11:10 – 11:35 |
Satomi Miwa, PhD “Identifying drugs to extend healthspan: a novel approach, old concepts” |
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11:35 – 12:00 |
Paul Robbins, PhD “Novel senotherapeutic approaches to extend healthspan” |
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12:00 – 12:25 |
Eduardo Chini, MD, PhD "NAD metabolism in aging and disease" |
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12:25 – 12:50 |
John Speakman, PhD “Impacts of graded calorie restriction” |
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12:50 – 13:00 |
Close |
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13:00 |
Lunch in Hadrians Brasserie |